Multipolar spindle definition
Multipolar spindles are spindle formations characteristic of cancer cells. Spindle formation is mostly conducted by the aster of the centrosome which it forms around itself. In a mitotic cell wherever two asters convene the formation of a spindle occurs.A. Within a multipolar spindle, a single kinetochore is more likely to face two spindle poles than it would be in a bipolar spindle. B. Because of the multipolar spindle geometry, a single kinetochore can easily bind microtubules emanating from two spindle poles rather than from just one pole. multipolar spindle definition
The primitive DPCs usually appearing as spindleshaped cells changed to flat multipolar cells with elongated shapes (Fig.
Multipolar spindle definition free
Multipolar spindles are spindle formations characteristic of cancer cells. Spindle formation is mostly conducted by the aster of the centrosome which it forms around itself. In a mitotic cell wherever two asters convene the formation of a spindle occurs.
Mutants have multipolar spindles in male meiosis and irregular mitotic figures in the larval neuroblasts, which is the result of aberrant behavior of the mitotic spindle during embryonic cleavage.
Multipolar mitosis Abberant mitotic figures, where the chromosomal material is pulled to more than two poles. Multipolarity is usually a phenomenon associated with the increase in centrosome number.
By screening a collection of PARP compounds for their ability to induce mitotic defects, we uncovered a robust correlation between PARP6 inhibition and induction of multipolar spindle (MPS) formation, which was phenocopied by PARP6 knockdown.
Most of the multipolar spindles exhibited a tripolar or tetrapolar morphology, although multipolar cells with 58 spindle poles (5. 4, 19. 5, and 7. 9 of all multipolar HCT116, HT29, and SW620, respectively) were also observed.
Despite the ability of multipolar cells to undergo bipolar cell division, the transient assembly of a multipolar spindle was recently shown to be strictly linked to the high rates of chromosome missegregation in CIN cancer cells (Ganem et al. , 2009; Silkworth et al. , 2009).
multipolar mitosis multipolar mitosis a pathologic form in which the spindle has three or more poles, resulting in the formation of a corresponding number of nuclei.
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