Transcriptional profiling definition
In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment.Current views on the control of cell development are anchored on the notion that phenotypes are defined by networks of transcriptional activity. The large amounts of information brought about by transcriptomics should allow the definition of these networks through the analysis of cellspecific transcriptional signatures. transcriptional profiling definition
Definition. Transcriptional profiling refers to a parallel analysis of gene expression. The profiling provides information about the physiological and metabolic state of
Transcriptional profiling definition free
Using microarraybased whole genome transcriptional profiling, the researchers determined that the pathogen uses its genetics to protect itself against not only antimicrobial compounds, but also against oxidative stress, osmotic stress, damage to its DNA and other threats to
transcriptional profiling of stem cells and their multilineage differentiation PROFILAGE TRANSCRIPTIONNEL DE CELLULES SOUCHES ET DIFFERENCIATION DE LIGNEES MULTIPLES DESDITES CELLULES the arrays are useful, for example,
Profiling the expression of large sets of transcripts has been greatly facilitated by the development and miniaturization of DNA array technology. This technique enables the concurrent screening of large sets of known and novel targets of druginduced change.
We used transcriptional and genomic profiling to define Burkitt's lymphoma more precisely and to distinguish subgroups in other types of mature aggressive Bcell lymphomas.
Scientists who use the techniquesand in many cases helped devise themexplain methods for transcriptional factor trafficking and posttranslational modification, the cytoplasmicnuclear trafficking of transcription factors, posttranslational modification and impact on function, and protocols for optimizing functional assays.
technologies for transcriptional profiling As previously discussed, the development of a complete molecularlevel picture of health and disease involves understanding metabolic processes at four distinct levels: genome (DNA sequence), transcriptome (mRNA profile), proteome (protein structure and interactions), and metabolic pathway.
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